Keywords: Alzheimer's disease, TDP-43, TARDBP Background Alzheimer's disease (AD), the leading cause of dementia, is a heterogeneous neurodegenerative disorder in terms of clinical presentations and the density and distribution of the cardinal neuropathologic lesions. The neuropatho-logic hallmarks of AD are senile plaques composed of

Conclusion and Relevance The results suggest that TDP-43 is an important brain pathology underlying cognitive decline and dementia in old 

Hyperphosphorylated transactive response DNA-binding protein 43 (TDP-43, encoded by TARDBP) proteinopathy has recently been described in ageing and in association with cognitive impairment, especially in the context of Alzheimer’s disease pathology.To explore the role of mixed Alzheimer’s disease and TDP-43 pathologies in clinical Alzheimer’s-type dementia, we

Disorders with concomitant TDP-43 pathology (1) Alzheimer’s disease (AD) is the most frequent dementia in adults over the age of 65, presenting with loss of episodic memory, followed by impairment in other cognitive domains and behavioural changes. Pathological hallmarks of AD include neuritic plaques (extracellular deposits of β-amyloid

temporal lobar degeneration with TDP-43 could be the pri- mary pathology in stage 6. Keywords TDP-43 · Alzheimer's disease · Staging ·.

TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease Authors Yao-Hsiang Shih 1 2 3 , Ling-Hsien Tu 1 4 , Ting-Yu Chang 1 5 , Kiruthika Ganesan 1 , Wei-Wei Chang 1 , Pao-Sheng Chang 1 , Yu-Sheng Fang 1 6 , Yeh-Tung Lin 1 5 , Lee-Way Jin 7 , Yun-Ru Chen 8 9 10 Affiliations

30/01/  · TDP-43 pathology is detected in 25% to 50% of AD cases, especially those with more severe clinical phenotype and greater Alzheimer type pathology, as well as AD cases with

TDP-43 has been reported to influence the clinical features of dementia, including cognitive deficits and the likelihood of dementia. Josephs 

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that says several things: (a) it's possible to have classic alzheimer's without mutated tdp-43, (b) it's possible to have classic alzheimer's tissue pathology (up to a point, no doubt) without apparent cognitive impairment, and (c) it's apparently possible (although very unlikely) to have mutated tdp-43, show alzheimer's pathology as well, and

First author Keith Josephs of the Clinic's branch in Rochester, Minnesota, identified TDP-43 pathology in 195 out of 342 autopsy AD cases—a "staggering" proportion that suggests TDP-43 inclusions appear in more than half of Alzheimer's patients, he said.